Comprehensive HHV-Related Services for Pharmaceutical and Biotechnology Research
At CD BioSciences, we specialize in providing comprehensive services aimed at advancing research and development in human herpesvirus (HHV)-related therapeutic areas. Our offerings cater to pharmaceutical companies, biotechnology firms, and research institutions during the research and preclinical stages, providing essential support for the development of antiviral therapies, vaccines, and diagnostics. With our deep expertise in virology, antiviral screening, bioanalytical testing, and preclinical evaluations, we ensure that our partners receive high-quality, accurate, and reliable results.
Our services are designed to support every stage of HHV-related research, from virus production and characterization to efficacy studies and safety testing. Below is an overview of our core service offerings:
Inquiry Now
Virology Services
We offer a wide range of virology services to support your HHV research and development projects:
Virus Production & Titration
Our virus production and titration services provide high-quality viral stocks for your research. We produce recombinant and wild-type viruses at various scales, ensuring the availability of well-characterized virus preparations for your assays.
Virus Purification & Characterization
We specialize in the purification and characterization of HHV. Our team uses advanced techniques such as ultracentrifugation and column chromatography to obtain pure viral preparations. Additionally, we perform comprehensive viral characterization to assess purity, stability, and infectivity, ensuring the consistency of your viral preparations for further experiments.
HHV Genome Sequencing
Through high-throughput sequencing technologies, we provide full-genome sequencing of HHV strains. This service is crucial for understanding virus mutations, evolutionary studies, and the identification of potential therapeutic targets.
Custom Virus Engineering
We offer custom virus engineering services to modify HHV genomes for research purposes. This includes gene knockouts, insertion of reporter genes, and other modifications that allow for detailed studies of viral biology and the effects of antiviral therapies.
Antiviral In Vitro Screening & Profiling
We offer comprehensive antiviral screening services to support your drug discovery efforts:
Our HTS platform allows you to rapidly test large libraries of compounds for antiviral activity. This service is designed to identify lead compounds that could be developed into effective antiviral drugs targeting HHV.
Efficacy Determination Assays
We perform a variety of efficacy assays to evaluate the antiviral activity of candidate compounds. These assays include viral inhibition, plaque reduction, and cytopathic effect (CPE) assays, providing critical information on the potency of antiviral agents.
High-Content Imaging for Viral Inhibition
Utilizing advanced imaging techniques, we provide high-content screening to assess viral inhibition at the cellular level. This service is particularly useful for studying the effects of compounds on viral replication and host-cell interactions.
Combination Therapy Studies
We offer combination therapy studies to investigate the synergistic or antagonistic effects of combining different antiviral compounds. This approach is essential for identifying novel therapeutic strategies and improving treatment efficacy.
Cytotoxicity
Assays
Our cytotoxicity assays determine the potential toxicity of antiviral compounds to host cells, ensuring that effective antiviral agents do not exhibit harmful effects on the cells being treated.
Mechanism of Action (MoA) Studies
Understanding the mechanism of action of antiviral compounds is essential for their development. We provide comprehensive MoA studies, including:
Target Identification & Validation
We identify and validate the molecular targets of antiviral compounds, providing insights into the biological pathways involved in viral replication and resistance.
Viral Lifecycle Stage Inhibition Assays
Our assays evaluate the effects of compounds on various stages of the viral lifecycle, such as attachment, entry, replication, and assembly, to pinpoint the stage where the drug acts most effectively.
Time-of-Addition/Removal Studies
These studies help determine the optimal timing for drug administration, allowing for more effective therapeutic strategies.
Antiviral Resistance Profiling
We assess the potential for viral resistance to develop in response to antiviral treatments, a critical aspect in the development of long-term therapies.
Host Factor Targeting Analysis
Our team evaluates how antiviral compounds affect host factors that facilitate viral replication, which is crucial for identifying host-targeted antiviral strategies.
Vaccine Pre-clinical Evaluation
Our vaccine evaluation services include both in vitro and in vivo assessments:
In Vitro Immunogenicity Assessment
We assess the immunogenicity of vaccine candidates by measuring immune responses such as antibody production, T-cell activation, and cytokine release.
In Vivo Vaccine Efficacy & Challenge Studies
We conduct in vivo studies to evaluate the protective efficacy of vaccine candidates in animal models. These studies simulate real-world viral challenges to determine the potential of the vaccine to prevent or mitigate viral infections.
Cell-Based Assay Services
Our cell-based assays provide insights into viral infection and treatment responses:
Custom Cell Line Development
We create custom cell lines tailored to your research needs, allowing for more relevant and precise assays for viral infection and drug screening.
Latency & Reactivation Models
We offer cell-based models to study viral latency and reactivation, essential for understanding chronic HHV infections and developing therapies to target these stages.
Co-culture Models
Our co-culture systems enable the study of virus-host interactions, providing a more comprehensive understanding of viral pathogenesis and therapeutic effects.
Organoid & 3D Tissue Models
We offer advanced 3D organoid models to study the effects of HHV on human tissues, providing more relevant data for therapeutic development.
Pre-clinical Model Services
Our preclinical model services include animal model development and efficacy studies:
Animal Model Development
We develop and validate animal models that mimic human HHV infections, providing critical in vivo data for drug efficacy and safety.
In Vivo Efficacy Studies
Our in vivo efficacy studies assess the therapeutic potential of antiviral compounds in animal models, offering valuable insights into their effectiveness and safety.
Preclinical Safety & Toxicology Services
We provide both in vitro and in vivo toxicology services to ensure the safety of your therapeutic candidates:
In Vitro Toxicology
We perform a variety of in vitro assays to evaluate the cytotoxicity and genotoxicity of antiviral compounds, ensuring that they are safe for further development.
In Vivo Toxicology (Non-GLP & GLP-compliant)
Our in vivo toxicology studies assess the safety of compounds in animal models, offering both non-GLP and GLP-compliant options depending on your regulatory needs.
Bioanalytical & Biomarker Services
Our bioanalytical and biomarker services support the development of antiviral therapies by providing key pharmacokinetic, biomarker, and immunogenicity data:
Method Development & Validation (GLP & Non-GLP)
We provide method development and validation for bioanalytical assays, ensuring that they meet GLP or non-GLP regulatory requirements.
Pharmacokinetics (PK) & Toxicokinetics (TK) Analysis
We conduct PK and TK studies to assess the absorption, distribution, metabolism, and excretion (ADME) properties of antiviral compounds.
Small Molecule Bioanalysis (LC-MS/MS)
Our LC-MS/MS bioanalysis services allow for the detection and quantification of small molecules, providing accurate data for compound screening and biomarker studies.
Large Molecule & Biologics Bioanalysis (LBA, ELISA)
We offer large molecule and biologic bioanalysis services, including ELISA and LBA, to measure antibodies and other biologic markers.
Viral Load & Biodistribution (qPCR, ddPCR)
We utilize qPCR and ddPCR technologies for viral load quantification and biodistribution studies, essential for understanding the spread of HHV in the body.
Viral Shedding
Analysis
We conduct viral shedding studies to evaluate how much virus is shed by infected individuals, which is critical for assessing transmission dynamics.
Immunogenicity & Anti-Drug Antibody (ADA) Assays
Our immunogenicity assays detect the presence of anti-drug antibodies (ADA) that can interfere with treatment efficacy and safety.
Biomarker Discovery & Validation
We assist in the discovery and validation of biomarkers associated with viral infections, providing insights into potential therapeutic targets.
References
- Article 1: "Human Herpesvirus: Pathogenesis and Therapy"
- Article 2: "Virology and Antiviral Drug Discovery: Current Approaches and Challenges"
FAQs
Custom Reviews
Review 1:
"CD BioSciences has been an invaluable partner in our HHV drug discovery efforts. Their expertise in antiviral screening and mechanism of action studies has accelerated our R&D process."
Review 2:
"We trust CD BioSciences for all our vaccine preclinical evaluations. Their in vivo studies are thorough, and we rely on their data for critical decision-making in our vaccine development programs."